| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
Human plasma gelsolin. |
|
產(chǎn)品描述 ： |
Gelsolin is a calcium-regulated, actin-modulating protein that binds to the plus ends of actin monomers and filaments, preventing monomer exchange. Gelsolin promotes the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Defects in gelsolin are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition, and is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals, causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure. |
| 適用物種 ： |
H, M, R |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
Gelsolin; Actin-depolymerizing factor; ADF; Brevin; AGEL |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSA with 0.09% sodium azide. Antibody was purified by anti-mouse IgG affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻(xiàn) ： |
Han C et al. 2013. Exp Biol Med. 238(11): 1318-27. PMID 24047794. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/gelsolin-antibody-1 |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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