| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
Mouse IgG2a |
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免 疫 原 ： |
Recombinant human cyclin D1 protein. |
|
產品描述 ： |
G1/S-specific cyclin-D1 (cyclin D1) is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Defects in cyclin D1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia.
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| 適用物種 ： |
H, M, R |
|
應用范圍 ： |
E, WB, IHC |
| 應用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; ICC: 1:100-1:500 |
| 別 名 ： |
Cyclin D1; G1/S-specific cyclin-D1; PRAD1 oncogene; BCL-1 oncogene; BCL1; PRAD1 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產品文獻 ： |
[1] Zhu J. et al. 2015. Mol Med Rep. doi:10.3892/mmr.2015.3284. PMID#25634369. Activin A regulates proliferation, invasion and migration in osteosarcoma cells. |
| 產品鏈接 ： |
http://www.abbiotec.com/antibodies/cyclin-d1-antibody-0 |
| 標 記 物 ： |
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產品說明 ： |
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