| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ASPP2. |
|
產(chǎn)品描述 ： |
Apoptosis-stimulating of p53 protein 2 (ASPP2) is a regulator that plays a central role in regulation of apoptosis and cell growth. ASPP2 regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. ASPP2 inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. ASPP2 impedes cell cycle progression at G2/M. The apoptosis-stimulating activity of ASPP2 is inhibited by its interaction with DDX42. |
| 適用物種 ： |
H, M, R |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
ASPP2; Apoptosis-stimulating of p53 protein 2; Tumor suppressor p53-binding protein 2; p53-binding protein 2; p53BP2; 53BP2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; TP53BP2; BBP |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻(xiàn) ： |
Xiangrong L et al. 2013. American Heart Association Journals. Stroke. 2013.44:1973-1980. PMID# 2369548. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/aspp2-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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