| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TCF-4. |
|
產(chǎn)品描述 ： |
T-cell-specific transcription factor 4 (TCF-4) participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. TFC-4 acts as repressor in the absence of CTNNB1, and as activator in its presence. TCF-4 is necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. Genetic variations in TCF-4 are associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM). NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance. |
| 適用物種 ： |
H, M, R, P |
|
應(yīng)用范圍 ： |
E, WB, IHC, IP |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500 |
| 別 名 ： |
Transcription factor 7-like 2; HMG box transcription factor 4; T-cell-specific transcription factor 4; T-cell factor 4; TCF-4; hTCF-4; TCF7L2; TCF4 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/tcf-4-antibody |
| 標 記 物 ： |
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產(chǎn)品說明 ： |
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