| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the center region of mouse p14/19ARF. |
|
產(chǎn)品描述 ： |
Cyclin-dependent kinase inhibitor 2A (P14ARF, or p19ARF in mouse) is capable of inducing cell cycle arrest in G1 and G2 phases. P14ARF acts as a tumor suppressor. P14ARF binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. P14ARF also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. |
| 適用物種 ： |
H, M, R |
|
應用范圍 ： |
E, WB, IHC |
| 應用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
Cyclin-dependent kinase inhibitor 2A, isoform 4; p14ARF; p19ARF; CDKN2A; CDKN2; MLM |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻 ： |
Yang Y-L et al.?2014. J Pathol. 233(2): 113-23. PMID 24648314. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/p14arf-antibody |
| 標 記 物 ： |
|
|
產(chǎn)品說明 ： |
|
