| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CCR-3. |
|
產(chǎn)品描述 ： |
C-C chemokine receptor type 3 (CCR-3) is a receptor for C-C type chemokine. CCR-3 binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. The activation of CCR-3 subsequently transduces a signal by increasing the intracellular calcium ions level. CCR-3 is an alternative coreceptor with CD4 for HIV-1 infection. Overexpression of CCR-3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR-3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T cell-mediated mucosal inflammation. |
| 適用物種 ： |
H, M, R |
|
應用范圍 ： |
E, WB, IHC |
| 應用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
CCR-3; C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR3; CKR3; Eosinophil eotaxin receptor; CD193; CMKBR3 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/ccr-3-antibody |
| 標 記 物 ： |
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產(chǎn)品說明 ： |
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