| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human c-SRC. |
|
產(chǎn)品描述 ： |
Proto-oncogene tyrosine-protein kinase Src (c-Src) is a non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, c-Src plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and c-SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins by PTK2B, c-Src phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. C-Src promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. |
| 適用物種 ： |
H, M, R, D, B |
|
應(yīng)用范圍 ： |
E, WB, IHC, IP |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500 |
| 別 名 ： |
SRC; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; p60-Src; c-Src; SRC1 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/c-src-antibody |
| 標(biāo) 記 物 ： |
|
|
產(chǎn)品說明 ： |
|
|
