| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated cyclic citrullinated peptide. |
|
產(chǎn)品描述 ： |
Citrulline is the deaminated form of arginine. Recently, the detection of citrillunated proteins, specifically keratin, has been of interest in the preliminary diagnosis of rheumatoid arthritis (RA). The epitope of keratin that is recognized by auto-antibodies is cyclic citrulline. Antibodies developed to recognize cyclic citrulline peptide (CCP) have provided earlier RA detection as compared to the historically used rheumatoid factor analysis. This antibody is raised against a peptide derived from human filaggrin cyclized by a disulfide bridge. Filaggrin aggregates intermediate keratin filaments by promoting disulfide bond formation. Filaggrin is modified by citrullination. |
| 適用物種 ： |
H |
|
應用范圍 ： |
E, WB, IHC |
| 應用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
CCP; Cyclic citrullinated peptide; citrulline |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/ccp-antibody |
| 標 記 物 ： |
|
|
產(chǎn)品說明 ： |
|
