| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PTEN. |
|
產品描述 ： |
PTEN (Phosphatase and tensin homolog) is a dual-specificity protein phosphatase, dephosphorylating tyrosine-, threonine- and serine-phosphorylated proteins. PTEN has also a lipid phosphatase activity that is critical for its tumor suppression function. PTEN antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. Defects in PTEN are the cause of numerous cancers such as in Cowden disease (breast, thyroid and skin cancer predisposition), Lhermitte-Duclos disease, and head and neck squamous cell carcinoma. |
| 適用物種 ： |
H, M, R |
|
應用范圍 ： |
E, WB, IHC |
| 應用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatase and tensin homolog; Mutated in multiple advanced cancers 1; MMAC1; TEP1; PTEN |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產品文獻 ： |
Pushpavalli S et al. 2011. Cancer Cell Int. 11:36. PMID# 22305408. |
| 產品鏈接 ： |
http://www.abbiotec.com/antibodies/pten-antibody-0 |
| 標 記 物 ： |
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產品說明 ： |
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