| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ER-alpha. |
|
產(chǎn)品描述 ： |
The estrogen receptor (ER-alpha) is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. ER-alpha can activate the transcriptional activity of TFF1. ER-alpha binds DNA as a homodimer, and can form a heterodimer with ESR2. ER-alpha interacts with FOXC2, MAP1S, SLC30A9, UBE1C and the coactivators NCOA3, NCOA5, NCOA6, and NCOA7. Genetic variations in ER-alpha are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. |
| 適用物種 ： |
H, M, R, Ck |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
Estrogen receptor; ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1; ESR1; ESR; NR3A1 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/er-alpha-n-term-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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