| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Von Willebrand Factor. |
|
產(chǎn)品描述 ： |
Von Willebrand Factor (VWF) plays a role in the maintenance of hemostasis, where it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. It also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease (VWD), a group of hemorrhagic disorders in which the von Willebrand factor is either quantitatively or qualitatively abnormal, resulting in altered platelet function. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII and impaired platelet adhesion. |
| 適用物種 ： |
H, M, R |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
Vwf; vWF; von Willebrand factor; F8VWF; von Willebrand antigen 2; von Willebrand antigen II; VWF |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻(xiàn) ： |
[1] Jiang Y. et al. 2015. Chongqing Medical University. 602:73-8. PMID#26149229 [2] Wu M. et al. 2014. Indian J Pharmacol. 46(2): 157-60. PMID# 24741185. [3] Wang X. et al. 2014. Stroke. 45(2): 619-62 |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/von-willebrand-factor-antibody |
| 標(biāo) 記 物 ： |
|
|
產(chǎn)品說明 ： |
|
