| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human c-ABL. |
|
產(chǎn)品描述 ： |
Proto-oncogene c-Abl (c-ABL) is a protein kinase that regulates key processes linked to cell growth and survival. c-ABL regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. C-ABL localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. c-ABL regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. A chromosomal aberration involving c-ABL1 is a cause of chronic myeloid leukemia. |
| 適用物種 ： |
M, R |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500 |
| 別 名 ： |
ABL1; Abelson murine leukemia viral oncogene homolog 1; Proto-oncogene tyrosine-protein kinase ABL1; c-ABL; p150; ABL |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻(xiàn) ： |
[1] Ma Y et al. 2016. Diabetes Res Clin Pract. 113: 171-8. PMID 26810274. [2] Chen X et al. 2013. Journal of Molecular Histology. March 21. PMID 23515840. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/c-abl-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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