| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term of human GABA-B-R1. |
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產(chǎn)品描述 ： |
GABA-B-R1 is a receptor for GABA. The activity of GABA-B-R1 is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. GABA-B-R1 plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. GABA-B-R1 is not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. |
| 適用物種 ： |
H, M, R, D, B, Hs |
|
應(yīng)用范圍 ： |
E, WB, IHC, IP |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500 |
| 別 名 ： |
Gamma-aminobutyric acid type B receptor subunit 1; GABA-B receptor 1; GABA-B-R1; Gb1; GABBR1 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/gaba-b-r1-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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