| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human HIF-PH3. |
|
產(chǎn)品描述 ： |
HIF-prolyl hydroxylase 3 (HIF-PH3) catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF-PH3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. HIF-PH3 plays a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. HIF-PH3 promotes cell death through a caspase-dependent mechanism. |
| 適用物種 ： |
H, M, R, B, D, P |
|
應(yīng)用范圍 ： |
E, WB, IHC, IP |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500 |
| 別 名 ： |
Prolylhydroxylase; Egl nine homolog 3; Hypoxia-inducible factor prolyl hydroxylase 3; HIF-prolyl hydroxylase 3; HIF-PH3; HPH-1; Prolyl hydroxylase domain-containing protein 3; PHD3; EGLN3 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/hif-ph3-antibody |
| 標 記 物 ： |
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產(chǎn)品說明 ： |
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