| 克隆類(lèi)型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within human FADD. |
|
產(chǎn)品描述 ： |
FAS-associated death domain protein (FADD) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. FADD is involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. Defects in FADD are the cause of recurrent infections associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM). IEHDCM is a condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4-CD8-TCR-alpha-beta+ T-cell counts, and elevated IL10 and FASL levels. |
| 適用物種 ： |
H, M, R |
|
應(yīng)用范圍 ： |
E, WB, IHC, IP |
| 應(yīng)用說(shuō)明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500 |
| 別 名 ： |
FADD; Protein FADD; Fas-associated protein with death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; Growth-inhbiting gene 3 protein; MORT1 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/fadd-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說(shuō)明 ： |
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