| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TLR2. |
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產(chǎn)品描述 ： |
Toll-like receptor family (TLR) has a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMP) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Toll-line receptor 2 (TLR2) cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. TLR2 acts via MYD88 and TRAF6 to lead to NFkB activation, cytokine secretion and inflammatory response. TLR2 is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, in lymph node and in spleen. Genetic variations in TLR2 are associated with susceptibility to leprosy, due to Mycobacterium leprae infection. |
| 適用物種 ： |
H, M, R, P, B |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 別 名 ： |
Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282; TLR2; TIL4 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻(xiàn) ： |
[1] Gomes FC et al. 2016. Andrology. 4(3): 473-80. PMID 27011054 [2] Garcia PV et al. 2016. BMC Cancer. 16:42. PMID 27389279 [3] Garcia PV. et al. 2015. Int J Clin Exp Pathol. 8(5): 4427-43. PMID 261 |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/tlr2-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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