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克隆類型：	Rat Monoclonal Antibody；Clone number：DTA-1
亞　　型：	Rat IgG2b
純化方式：	Concentration：0.2 mg/ml
緩沖液：	PBS pH 7.2, 0.09% NaN3, 0.2% BSA
產(chǎn)品描述：	GITR, Glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18, and AITR (in humans). It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ T regulatory (Treg) cells. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation, and abrogate the inhibitory functions of CD4+CD25+ Treg cells. In vivo activation GITR causes development of autoimmune diseases and restores the suppressed immune responses.
適用物種：	Mouse
應(yīng)用范圍：	FC
應(yīng)用說(shuō)明：	The amount of the reagent is suggested to be used ≤ 0.25 μg /10^6 cells in 100 μl
保存條件：	Store at 4°C and protected from prolonged exposure to light. Do not freeze.
標(biāo) 記物：	PE
產(chǎn)品說(shuō)明：

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