| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
mouse IgG1 |
|
產品描述 ： |
The CD42b (HIP1) antibody recognizes a heterodimer glycoprotein (GPIbα) that contains an α chain (CD42b, 145 kDa) and a β chain (CD42c, 22 kDa) linked by a disulfide bond forming a noncovalent complex with CD42a (GPIX) and d. CD42b antigen is expressed on platelets and megakaryocytes. The GPIb/IX complex (CD42a-d) serves as a receptor for von Willebrand Factor (vWF) and thrombin, and mediates adhesion of platelets to subendothelium of damaged vascular walls. The absence of the CD42 complex leads to the Bernard-Soulier Syndrome (BSS). The CD42b (HIP1) antibody inhibits the ristocetin-dependent binding of vWF to platelets, ristocetin-induced platelet agglutination, and partially inhibits collagen-induced aggregation. |
| 適用物種 ： |
H |
|
應用范圍 ： |
B, E, FC, IHC |
| 應用說明 ： |
Purified antibody is suitable for immunohistochemistry with acetone-fixed frozen sections. The antibody also inhibits the ristocetin-dependent binding of vWF to platelets, ristocetin-induced platelet agglutination, and partially inhibits collagen-induced aggregation. E: 1:500-1:1,000; FC: 1:200-1:1,000; IHC: 1:200-1:500 |
| 別 名 ： |
CD42b; Platelet glycoprotein Ib alpha chain; Glycoprotein Ibalpha; GP-Ib alpha; GPIb-alpha; GPIbA; Antigen CD42b-alpha; Glycocalicin |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產品文獻 ： |
[1] Chen Z et al. 1987. Chinese Science Bulletin. 24: 1902. [2] Knapp W et al. eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. P798, 1078, Oxford University Press, New York. |
| 產品鏈接 ： |
http://www.abbiotec.com/antibodies/cd42b-hip1-antibody |
| 標 記 物 ： |
|
|
產品說明 ： |
|
