| 克隆類型 ： |
Mouse Monoclonal Antibody |
|
亞 型 ： |
mouse IgG1 |
|
產(chǎn)品描述 ： |
The CD41 (HIP11) antibody recognizes a 140-kDa glycoprotein which is the α subunit of the CD41/CD61 (GPIIb/IIIa, αIIbβ3) complex called glycoprotein IIb (GPIIb). GPIIb is a calcium-dependent, no covalently associated heterodimer and contains a heavy chain (GPIIbα) and a light chain (GPIIbβ) linked by a single disulfide bond. The CD41 antigen is strictly expressed on platelets and platelet precursors (megakaryocytes). The CD41/CD61 complex is the receptor for fibrinogen, fibronectin and von Willebrand factor, and plays a central role in platelet activation and aggregation. The GPIIb/IIIa may be absent or strongly reduced in Glanzmann’s thrombasthenia (GT). The CD41 (HIP8) antibody inhibits platelet aggregation and ATP secretion induced by ADP, thrombin and collagen. The CD41 (HIP11) antibody reacts with α and β subunits of GPIIb/IIIa (CD41/CD61) complex. |
| 適用物種 ： |
H |
|
應用范圍 ： |
E, FC, IHC |
| 應用說明 ： |
Purified antibody is suitable for immunohistochemistry with acetone-fixed frozen sections. E: 1:500-1:1,000; FC: 1:200-1:1,000; IHC: 1:200-1:500 |
| 別 名 ： |
Integrin alpha-IIb; Platelet membrane glycoprotein IIb; GPalpha IIb; GPIIb; CD41 antigen; ITGA2B; GP2B; ITGAB |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻 ： |
[1] Romaniuk M et al. 2012. The FASEB Journal. 26(7):2488-2798. PMID# 22456341. [2] Wu XW. et al. 1989. National Medical J. of China. 69(8) :427. [3] Chen Z et al. 1987. Chinese Science Bulletin. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/cd41-hip11-antibody |
| 標 記 物 ： |
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產(chǎn)品說明 ： |
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