| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PDGF-B. |
|
產(chǎn)品描述 ： |
Platelet-derived growth factor (PDGF-A and PDGF-B subunits) is a potent mitogen for cells of mesenchymal origin. Binding of PDGF to its receptor PDGFR triggers a variety of cellular responses. PDGF is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and heal the wound. PDGF consists of antiparallel disulfide-linked dimer of non identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. A-A and B-B homodimers as well as A-B heterodimers bind to the PDGF receptor. A chromosomal aberration involving PDGF-B is a cause of dermatofibrosarcoma protuberans (DFSP), an uncommon aggressive tumor of the deep dermis and subcutaneous tissue. PDGF-B is available under the name Regranex (Ortho-McNeil) to promote healing in diabetic neuropathic foot ulcers. |
| 適用物種 ： |
H, M, R |
|
應(yīng)用范圍 ： |
E, WB, IHC |
| 應(yīng)用說明 ： |
E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500 |
| 別 名 ： |
Platelet-derived growth factor subunit B; PDGF subunit B; Platelet-derived growth factor B chain; Platelet-derived growth beta polypeptide; PDGF-2; c-sis; Becaplermin; PDGFB; PDGF2; SIS |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/pdgf-b-antibody |
| 標(biāo) 記 物 ： |
|
|
產(chǎn)品說明 ： |
|
