| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of HCV-NS3. |
|
產品描述 ： |
Hepatitis C virus (HCV) helicase (non-structural protein 3, NS3) is involved in HCV genome replication and is considered a target for inhibition of HCV. Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. The protease is self-inactivated following maturation. NS3 has three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease in association with NS4A is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. NS3 cleaves and inhibits the host antiviral protein MAVS. |
| 適用物種 ： |
H, Vs |
|
應用范圍 ： |
E, WB, IHC |
| 應用說明 ： |
E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500 |
| 別 名 ： |
Genome polyprotein hepatitis virus C; Helicase NS3; Non-structural protein 3; Hepacivirin; NS3P; p70 |
|
形 態(tài) ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產品鏈接 ： |
http://www.abbiotec.com/antibodies/hcv-ns3-antibody |
| 標 記 物 ： |
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產品說明 ： |
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