產(chǎn)品貨號(hào)Reference:              CAN-DHT-280
檢測(cè)方法Kit Type:                 Competitive ELISA
規(guī)格Kit Size:                         96-well break-apart microplate
靈敏度Sensitivity:                 6 pg/mL
檢測(cè)樣本Sample Type:         Human serum / 50 μL
校準(zhǔn)范圍Calibrator Range:  25–2500 pg/mL
檢測(cè)時(shí)間Total Assay Time:  75 minutes

背景介紹：

5雙氫睪酮(α-dihydrotone，DHT)是一種類似于睪酮和雄烯二酮的甾體，屬于雄激素類。
DHT是一種C19類固醇，具有雄激素活性。雄激素的大量產(chǎn)生主要發(fā)生在睪丸的間質(zhì)細(xì)胞中。雄激素在血液中循環(huán)與蛋白質(zhì)結(jié)合，特別是性激素結(jié)合球蛋白(SHBG)和白蛋白。微量的類固醇在血液中以未結(jié)合的形式循環(huán)，被稱為游離組分。DHT對(duì)SHBG的親和力至少是睪酮的三倍。在男性中，大約70%的DHT來(lái)自外周睪酮的轉(zhuǎn)化，而在女性中，大部分DHT來(lái)自雄烯二酮。
5α-dihydrotestosterone (DHT) is a steroid similar to testosterone and androstenedione, which belong to a class called androgens.
DHT is a C19 steroid and possesses androgenic activity. The bulk of androgen production takes place mainly in the Leydig cells of the testes. Androgens circulate in the blood bound to proteins, especially sex hormone binding globulin (SHBG) and albumin. A trace amount of these steroids circulate in the unbound form in the blood and are referred to as the free fractions. DHT has at least three times the binding affinity for SHBG than testosterone. In males about 70% of DHT is derived from peripheral conversion of testosterone, while in females most of the DHT is derived from androstenedione.