產(chǎn)品說明 ：
產(chǎn)品貨號Reference: CAN-TSH-6030
檢測方法Kit Type: Sandwich LIA
規(guī)格Kit Size: 96-well break-apart microplate
靈敏度Sensitivity: 0.13 μIU/mL
檢測樣本Sample Type: Human serum / 50 μL
校準范圍Calibrator Range: 0.15–30 μIU/mL
檢測時間Total Assay Time: 90 minutes
背景介紹：
促甲狀腺激素(TSH)是垂體前葉分泌的一種分子量為28KD的糖蛋白激素。促甲狀腺激素有兩個亞基，即α和β。促甲狀腺激素的α亞單位與LH、FSH和α糖蛋白激素中的hCG亞單位相似。促甲狀腺激素(TSH)正向刺激甲狀腺激素T4和T3的產(chǎn)生。循環(huán)T4和T3通過負反饋調(diào)節(jié)TSH分泌。促甲狀腺激素(TSH)的產(chǎn)生也受到下丘腦分泌的促甲狀腺激素釋放激素(TRH)的積極控制。血清TSH的測定被認為是診斷原發(fā)性和繼發(fā)性甲狀腺功能減退癥最敏感的指標。在原發(fā)性甲狀腺功能減退癥中，甲狀腺激素的產(chǎn)生受到損害，TSH水平通常會很高。在因垂體或下丘腦病變而導致甲狀腺激素水平低下的繼發(fā)性或特發(fā)性甲狀腺功能減退癥中，TSH水平通常較低。此外，敏感的TSH檢測也能區(qū)分甲狀腺功能亢進癥和正常甲狀腺人群。在大多數(shù)甲狀腺功能亢進癥中，TSH通常被抑制到低于正常水平。建議同時測定TSH和甲狀腺激素，作為甲狀腺功能狀態(tài)的臨床評價指標。但如果只有一項甲狀腺功能測試，那么TSH就是一種測試。TSH測定也有助于監(jiān)測接受甲狀腺素替代治療的患者。
Thyroid stimulating hormone (TSH) is a glycoprotein hormone of 28KD secreted by the anterior pituitary gland. TSH has two subunits, namely α and β. The α subunit of TSH is similar to the α subunit found in the LH, FSH and hCG glycoprotein hormones. The β subunit however, is speci? c and differs from hormone to hormone.
TSH stimulates positively the production of thyroid hormones T4 and T3. Circulating T4 and T3 regulate the TSH secretion by negative feedback. TSH production is also under the positive control of thyrotropin-releasing hormone (TRH), which is secreted by hypothalamus.
Measurement of serum TSH is generally regarded as the most sensitive indicator available for the diagnosis of primary and secondary hypothyroidism. In primary hypothyroidism, where there is impaired production of thyroid hormones, the TSH level is typically highly elevated. In secondary or tertiary hypothyroidism where the thyroid hormones are low as a consequence of pituitary or hypothalamic lesions, the TSH level is usually low.
Further, a sensitive TSH assay is also able to differentiate the hyperthyroidism from the euthyroid population. TSH is typically suppressed to subnormal levels in most hyperthyroidism.
It is recommended to assay both TSH and thyroid hormones for the clinical assessment of thyroid status. But if there were to be only one test to be prescribed for thyroid function, TSH would be the test. TSH determinations are also helpful to monitor patients who receive thyroxine replacement therapy.
注：本產(chǎn)品僅用于科研用途，不能直接用于人體或臨床診斷使用。
