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序 列 ： Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu or KKALRRQETVDAL |
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分 子 量 ： 1527.8 g/mol |
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純 度 ：Purity > 95% by HPLC
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形 態(tài) ：Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
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溶 解： Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. |
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保存條件 ：Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C. |
| 別 名 ：Calcium/calmodulin-dependent protein kinase type II alpha chain; CaM-kinase II alpha chain; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2A; CAMKA; KIAA0968 |
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產(chǎn)品描述 ：Autocamtide-2 is a highly selective peptide substrate for calcium/calmodulin-dependent protein kinase II (CaMKII), which belongs to the CAMK Ser/Thr protein kinase family. The sequence derives from the Thr-286 autophosphorylation site of the alpha subunit of CaMKII. Autocamtide-2 contains the R-X-X-S/T consensus site surrounded by basic residues for improved binding to phosphocellulose. CaMKII is a prominent kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CaMKII phosphorylates Autocamtide-2 with a Km of 2 uM whereas protein kinase C (PKC) has a Km > 50 uM and protein kinase A (PKA) has no activity. |
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產(chǎn)品鏈接 ：http://www.ABBIOTEC.com/peptides/autocamtide-2%2525C2%2525A0-peptide
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